Endocrine Abstracts

Introduction: Krüpel-like factor 4 (KLF4) is a zinc-finger-type transcription factor expressed in a range of tissues that plays multiple functions. KLF4 is expressed in neural stem cells and is critical to neuronal differentiation. Recent evidence suggests that KLF4 also plays an important role in the central regulation of energy balance. In vitro studies show that KLF4 is a transcriptional regulator of agouti–related protein (AgRP), essential to the hyperph...

Introduction: p53 is transcription factor widely known because of its antitumoral actions. New evidences suggest that p53 also play a key role in the regulation of metabolic homeostasis and specifically in the lipid metabolism.Objective: We hypothesize that the chemical activation of p53 with low doses of doxorubicin could ameliorate the lipid metabolism in in vitro models of liver steatosis.Methods: We treated with low co...

Introduction: Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide which is located in the lateral hypothalamus and regulate the energy balance. MCH deficient mice are hypophagic, lean and do not develop hepatosteatosis when fed on high fat diet. The MCH increases food intake and adiposity, so we sought to investigate the role of the MCH on adipocyte and hepatic metabolism.Methods: MCH were chronically administered into the lateral ventricle...